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Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine, acting as a less potent inhibitor of GlyT2. It inhibits glycine responses by 16.8% at concentrations up to 3 μM.
Inhibits glycine transport by GlyT2.
Used in research for Alzheimer's disease, mild cognitive impairment, and subjective memory complaint.
Soluble in ethanol and DMSO for various in vitro applications.
Solid storage at -20°C, sealed and away from moisture.
In-solvent storage at -80°C for 6 months or -20°C for 1 month.
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A conditionally essential nutrient; facilitates the transport of long-chain fatty acids into the mitochondrial matrix for β-oxidation, has other diverse roles on metabolism, and is involved in the maintenance of CoA stores; plasma and/or tissue levels are decreased in primary L-carnitine deficiency; serum and tissue levels are also reduced in secondary L-carnitine deficiencies
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L-Carnitine inner salt (CAS 541-15-1) is a naturally occurring quaternary ammonium compound prevalent in mammalian tissues particularly in skeletal and cardiac muscle It facilitates the transport of long-chain fatty acids into mitochondria for -oxidation thereby playing a critical role in cellular energy metabolism By modulating substrate utilization L-carnitine influences the balance between glucose and lipid metabolism It is widely employed in metabolic research to study energy regulation mitochondrial function and disorders involving altered fatty acid oxidation
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NS 1643 (CAS 448895-37-2) is a small-molecule partial agonist of the human hERG potassium channel exhibiting an EC50 of 10 5 M In murine models of triple-negative breast cancer (TNBC) NS 1643 has been shown to inhibit tumor growth via specific signaling pathways Experimental studies demonstrate that NS 1643 suppresses both migration and invasion of breast cancer cells Due to these properties NS 1643 serves as a valuable tool for investigating hERG channel modulation and its impact on cancer cell behavior with potential applications in preclinical oncology research
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